在儿童中与肠道病毒D68相关的呼吸系统疾病
Benjamin R Clopper1, Adriana S Lopez1, Leah A Goldstein1
1US Centers for Disease Control and Prevention, Atlanta, Georgia.
JAMA network open
|May 8, 2025
概括
肠道病毒D68 (EV-D68) 在儿童中引起严重的呼吸系统疾病,即使在没有潜在疾病的儿童中也是如此. 除喘或反应性呼吸道疾病以外的并发症增加了住院的严重程度和重症监护需求.
科学领域:
- 儿童传染病 儿童传染病
- 呼吸道病毒感染 呼吸道病毒感染
- 流行病学 流行病学
背景情况:
- 肠道病毒D68 (EV-D68) 是儿童急性呼吸道疾病 (ARI) 的重要原因,但美国对其流行病学和临床严重性的监测和理解有限.
- 关于美国儿童需要医疗护理的EV-D68感染相关的特定风险因素和结果的数据有限.
研究的目的:
- 在美国寻求ARI护理的儿童中描述EV-D68的流行病学和临床严重程度.
- 确定与患有EV-D68感染的住院儿童严重结局相关的因素.
主要方法:
- 在7个美国学术医疗中心使用新疫苗监测网络 (2017-2022) 的数据进行了横截面研究.
- 积极的前性监测将18岁以下的儿童纳入ARI和实验室确认的EV-D68感染.
- 多变量逻辑回归分析了在没有病毒共检测的情况下住院的儿童中与补充氧气或重症监护入院相关的因素.
主要成果:
- 976名患有EV-D68的儿童被确定; 536人需要住院治疗.
- 在住院儿童中,37.1%患有喘/RAD,14.4%患有其他潜在疾病.
- 非喘/RAD并发症与需要补充氧气 (aOR,2.72) 或重症监护 (aOR,3.09) 的可能性增加有关.
结论:
- EV-D68与儿童的严重疾病有关,包括其他健康儿童.
- 患有喘或反应性呼吸道疾病以外的并发症的儿童在住院治疗EV-D68.8时面临更高的严重后果风险.
- 调查结果强调需要加强EV-D68监测和临床管理策略.
相关概念视频
Pneumonia V: Nursing management and Prevention
1.7K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
1.7K
Common Respiratory Disorders
177
Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
177
Pneumonia II: Pathophysiology
189
The pathophysiology of pneumonia involves the following steps:
189
Pneumonia IV: Management
271
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
271
Pneumonia III: Complications and Assessment
127
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
127
Pulmonary Cycle: Exhalation
1.3K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.3K


