免疫检查点抑制剂在非小细胞肺癌中的危害益处平衡

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James Heyward1,2, Catherine R Lesko2, Joseph C Murray3

  • 1Center for Drug Safety and Effectiveness, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

JAMA oncology
|May 8, 2025
PubMed
概括

在肺癌中,免疫检查点抑制剂 (ICI) 加上化疗提供了生存益处,但增加了严重的副作用,特别是在一线治疗中. 谨慎的决策至关重要,特别是对于代表性不足的患者群体.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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