在亲密时刻的药物转移可以在兴奋剂控制期间产生不利的分析结果. 关于使用利甘德罗尔的案例报告
Pascal Kintz1,2, Laurie Gheddar1
1Institut de médecine légale, 11 rue Humann, 67000 Strasbourg, France.
Journal of analytical toxicology
|May 8, 2025
概括
选择性雄激素受体调节剂 (SARMs) 可以通过亲密接触在个人之间转移. 一名女运动员在证明丈夫偶然接触了利甘德罗尔后,被清除了兴奋剂指控.
科学领域:
- 药理学 药理学是指药理学的学科.
- 反兴奋剂科学反兴奋剂科学
背景情况:
- 选择性雄激素受体调节剂 (SARMs) 由世界反兴奋剂机构 (WADA) 禁止,因为它们具有提高表现的潜力.
- 在一名运动员的尿液中检测到一种流行的SARM - - Ligandrol,导致违反了反兴奋剂规则.
- 运动员对违规行为提出异议,暗示意外暴露,并要求进行头发检查.
研究的目的:
- 调查通过亲密接触偶然接触SARM的可能性.
- 为了确定头发分析是否可以在潜在的间接暴露后检测到利甘德罗尔.
主要方法:
- 尿液样本最初对利甘德罗尔代谢物,bishydroxy-ligandrol的检测结果呈阳性.
- 毛发样本是在尿液采集后大约7周收集并细分的.
- 用液体染色学-并联质谱学分析了Ligandrol在头发部分.
主要成果:
- 在运动员的头发样本中没有检测到利甘德罗尔,量化极限为1ppg/mg.
- 在运动员丈夫的头发样本中检测到利甘德罗尔,确认他使用了该物质.
- 运动员通过体液交换的偶然暴露的解释得到了研究结果的支持.
结论:
- 通过亲密接触,个人之间的药物传输是偶然接触Ligandrol等物质的可信途径.
- 头发检测可以在反兴奋剂案件中成为一个有价值的工具,用于调查间接物质暴露的说法.
- 这一案例凸显了在体育仲裁中考虑非故意兴奋剂场景的重要性.
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