过早分娩中的肥胖悖论:一个病例对照研究
Krystal Hunter1,2,3, Michael Ehrlich3, Jocelyn Mitchell-Williams4,5
1Department of Medicine, Cooper Medical School of Rowan University, Camden, New Jersey, United States of America.
PloS one
|May 8, 2025
概括
孕前母亲的体重指数 (BMI) 对早产 (PTB) 的影响因社会经济地位而异. 较低社会经济地位的女性表现出肥胖悖论,BMI和PTB风险之间存在曲线关系.
科学领域:
- 产科和妇科 产科和妇科
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 过早出生 (PTB) 是新生儿死亡的主要原因,全球新生儿死亡率正在上升.
- 现有的关于母亲怀孕前体重指数 (BMI) 和PTB的研究产生了不一致的结果.
- 社会经济地位 (SES) 对BMI-PTB关系的影响需要进一步研究.
研究的目的:
- 调查母亲怀孕前的BMI与社会经济地位 (SES) 与早产 (PTB) 率相关的相互作用.
- 解决关于BMI,SES和PTB之间的复杂关系的知识差距.
- 评估社会阶级对母亲的BMI和PTB之间的关联的影响.
主要方法:
- 采用了一种病例控制研究设计.
- 利用国家生命统计系统 (2020-2022) 的出生数据.
- 分析了母亲怀孕前BMI,SES和PTB之间的关系,并结合了多项BMI术语.
主要成果:
- 母亲的BMI是低社会经济地位 (LSES) 的女性PTB的重要因素.
- 在LSES女性中观察到一个"肥胖悖论",在LSES女性中,增加的BMI最初降低了PTB几率 (OR=0.923,P<0.001),然后升高.
- 在LSES女性中,BMI-PTB关系是曲线的,与SES女性中发现的非显著关联不同.
结论:
- 该研究发现,低社会经济地位的母亲在早产中存在肥胖悖论.
- 母亲的BMI和早产之间的关系是曲线的,而不是线性的,特别是对于LSES女性.
- 结合SES和多项式BMI术语,可以更细致地了解PTB风险因素.
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