仅含有A2β-素的牛奶对肠道微生物群的有益影响:单中心,随机,双盲,交叉研究
Chin-Hee Song1, Nayoung Kim1,2,3, Yonghoon Choi1,2
1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
PloS one
|May 8, 2025
概括
在与牛奶相关的胃肠道不适的人群中,A2牛奶消费显著改变了肠道微生物群,促进了Bifidobacterium和Blautia等有益细菌. 这表明A2牛奶可能是一个适合的替代品,对于那些经历消化问题与普通牛奶.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 牛奶含有A1和A2β-氨酸 (β-氨酸).
- 仅含有A2β-casein的A2牛奶被建议比A1/A2牛奶提供胃肠道 (GI) 益处.
- 饮用牛奶后经历胃肠道不适的人可能已经改变了肠道微生物群的反应.
研究的目的:
- 为了研究A2牛奶消费对肠道微生物群组成的影响.
- 为了比较A2牛奶与A1/A2牛奶对肠道微生物群的影响,在韩国一群患有胃肠道不适的人群中.
- 为了确定与A2牛奶摄入相关的特定微生物和功能变化.
主要方法:
- 一项涉及35名参与者,在牛奶消费后出现胃肠道不适的研究.
- 使用16S rRNA基因测序在2周干预前后分析便DNA.
- 使用的β多样性 (通用UniFrac),α多样性,LEfSe,PICRUSt和斯皮尔曼相关性分析.
主要成果:
- 与A1/A2牛奶不同的是,A2牛奶的消费显著改变了肠道微生物群的组成 (p=0.04),而A1/A2牛奶的消费显著改变了肠道微生物群的组成 (p=0.04).
- 在A2和A1/A2牛奶消费者之间观察到微生物群的显著差异 (p=0.031).
- 增加的有益微生物 (Bifidobacterium, Blautia) 和丰富的微生物运输系统被发现与A2牛奶.
结论:
- 两周的A2牛奶摄入量显著改变了肠道微生物群,增强了有益细菌和相关功能.
- A2 牛奶消费促进了肠道中特定的微生物转移和功能途径.
- 对于与牛奶消费相关的胃肠道不适的人来说,A2牛奶是一个潜在的替代品.
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