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Updated: May 22, 2025

Quantifying Subcellular Ubiquitin-proteasome Activity in the Rodent Brain
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对无处不在素独立的midnolin-proteasome通路的结构洞察

Nagesh Peddada1, Xue Zhong1, Yan Yin1

  • 1Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.

Proceedings of the National Academy of Sciences of the United States of America
|May 8, 2025
PubMed
概括

米德诺林 (MIDN) 增强蛋白质酶活性和B细胞恶性瘤存活率. 它的泛素类域结合RPN11,而其C端螺旋结合RPN1,将基质定位为降解.

关键词:
在中午,中午.在 RPN1/PSMD2 中使用.在 RPN11/PSMD14 中使用.这是一个 UBL 域名.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.

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