根据现场自动化固相提取和便携式质谱技术,在废水中快速选非法药物
Liangming Luo1, Chenlu Wang2, Yong Wu2
1Faculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo, PR China; Zhejiang Engineering Research Center of Advanced Mass Spectrometry and Clinical Application, Institute of Mass Spectrometry, Ningbo University, Ningbo 315211, PR China.
Journal of chromatography. A
|May 8, 2025
概括
这项研究开发了一种快速的现场方法,使用便携式质谱仪在废水中检测胺,可卡因和可代因. 绿色分析方法为非法药物监测提供了传统实验室分析的经济有效的替代方案.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
- 法医科学 法医科学 法医科学
背景情况:
- 废水分析对于监测非法毒品使用趋势至关重要.
- 现场检测方法在废水分析中越来越受欢迎.
- 传统的实验室方法耗时且昂贵.
研究的目的:
- 建立一个在废水中检测胺 (KET),可卡因 (COC) 和可代因 (COD) 的现场检测方法.
- 为快速查优化样品准备和质谱参数.
- 评估方法的性能和绿色化学方面.
主要方法:
- 使用自动固体相提取 (SPE) 装置与HLB弹进行样本丰富和净化.
- 采用一台便携式质谱仪与大气下压力化学电离 (APCI) 源进行定量分析.
- 优化了SPE条件和APCI源参数;在选择的离子监测 (SIM) 模式下进行了定量分析.
主要成果:
- 在140μg/L范围内实现了KET,COC和COD的良好的线性 (R2>0.99).
- 获得的检测极限 (LODs) 在0.300.42μg/L之间.
- 报告的高恢复率从70.52%到118.56%不等.
结论:
- 开发的方法可以快速地在现场选废水中的非法药物.
- 这种方法大大降低了样品运输和储存成本,缩短了检测周期.
- 评估表明,该方法是一种可行的绿色替代方案,用于基于废水的药物监测.
更多相关视频
相关概念视频
High-Performance Liquid Chromatography: Types of Detectors
369
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
369
Mass Spectrometry: Complex Analysis
652
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
652


