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通过可持续工艺开发的弹性类似聚合物纳米系统,有效的抗氧化多的眼部输送

Luna Krstić¹, Reinaldo Vallejo², Soraya Rodriguez-Rojo³

¹Instituto de Oftalmobiología Aplicada (IOBA), Universidad de Valladolid, Paseo Belén 17, 47011 Valladolid, Spain.

International journal of pharmaceutics

|May 8, 2025

概括

这项研究开发了用于干眼病治疗的新型弹性类似聚合物纳米颗粒,利用可持续的超临界CO2. 这些配方有效地将抗氧化剂奎尔丁和白醇输送到角膜细胞中,显示出眼睛治疗的前景.

科学领域:

生物材料科学生物材料科学
眼科医生眼科眼科
纳米技术纳米技术

背景情况:

干眼疾病 (DED) 需要先进的治疗策略.
弹性类似聚合物 (ELP) 为药物输送提供独特的刺激反应性质.
可持续的制造方法对纳米医学至关重要.

研究的目的:

开发一种基于ELP的颗粒物系统,用于局部眼科输送抗氧化剂.
使用超临界二氧化碳 (scCO2) 进行ELP微粒的环保配方.
为了评估素 (QUE) 和复星 (RSV) 装载的ELP纳米颗粒对DED的治疗潜力.

主要方法:

使用scCO2进行超临界抗溶剂 (SAS) 工艺,以制备载有QUE和/或RSV的ELP微粒.
在生理温度下微粒子转化为纳米粒子的表征.
用人类角膜上皮细胞 (HCE) 进行体外生物相容性测试.
细胞内活性氧物种 (ROS) 清除活动的评估.
在猪眼模型中对角膜上皮的向和细胞吸收的ex vivo评估.

主要成果:

通过SAS成功生产载有QUE,RSV或两者的固体ELP微粒.
微粒在生理温度下转化为纳米粒子 (56.761.5 nm),使得持续释放.
ELP配方表现出与HCEs的良好生物相容性.
观察到显著的细胞内ROS清理活动.
光标记的颗粒在ex vivo模型中显示出有效的细胞吸收和向向角膜上皮的向传递.

结论:

使用scCO2制成的基于ELP的纳米粒子代表了DED的可持续和有效的药物输送系统.
ELP的刺激反应性促进了抗氧化物多的受控释放.
开发的系统显示出用于局部眼部药物递送的显著潜力,准角膜上皮质并减少氧化应激.

关键词:

干眼疾病是干眼的疾病.类似弹性纤维的聚合物.眼科的分娩是眼科的分娩奎尔丁 (Quercetin) 是一种青素.复星醇是一种超临界的CO2 超临界抗溶剂工艺的超临界抗溶剂工艺.

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