基因组医学中的分布性成本效益分析:解决健康公平问题的考虑因素
Hadley Stevens Smith1, James Buchanan2, Ilias Goranitis3
1Department of Population Medicine, Harvard Medical School, Boston, MA USA; Center for Bioethics, Harvard Medical School, Boston, MA USA.
概括
分布性成本效益分析 (DCEA) 可以指导基因组医学中的公平资源分配. 应用DCEA需要仔细考虑数据权益和子组变化,以确保公平的访问和结果.
科学领域:
- 基因组医学是一种基因组医学.
- 卫生经济学 卫生经济学
- 卫生公平性健康公平性
背景情况:
- 基因组医学的快速增长引发了人们对因研究和获取差异而加剧的健康不平等的担忧.
- 分布性成本效益分析 (DCEA) 量化了股权效率权衡,有助于公平地分配资源.
- 了解DCEA在基因组医学中的应用对于解决潜在的健康差异至关重要.
研究的目的:
- 在基因组医学背景下批判性地研究DCEA的应用.
- 调整现有的框架来评估基因组干预的分布影响.
- 讨论基因组医学中DCEA的数据公平性和证据要求.
主要方法:
- 调整了"不平等阶梯"的概念框架,以绘制基因组医学干预的因果途径.
- 对基因组医学特有的分布影响评估的明确步骤.
- 讨论了对基因组医学干预的数据公平性考虑和证据需求.
主要成果:
- 在基因组医学中,干预的需要,接收和结果在不同社会群体之间可能会有很大的差异.
- 研究应该区分生物学和社会因素,赋予代表性不足的人口权力,并准确评估子组结果变化.
- 开发将非健康结果纳入DCEA的方法对于基因组医学至关重要.
结论:
- 最佳实践DCEA应用程序可以促进关于覆盖和实施健康公平的透明讨论.
- 这项工作为使用DCEA在基因组医学和其他公平敏感临床领域的研究人员提供了指导.
- 在医疗保健资源分配中,DCEA是导航复杂的公平考虑的宝贵工具.
更多相关视频
09:34Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
33.4K
11:35Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
Published on: August 21, 2016
12.9K
相关概念视频
02:02Genomics
35.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.3K
01:29Issues And Trends In Healthcare Delivery System
5.5K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.5K
03:00Next-generation Sequencing
86.1K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
86.1K
01:11Genome-wide Association Studies-GWAS
12.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.1K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
106
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
106
01:25What is Population Genetics?
57.0K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
57.0K