如何识别患有低骨矿物质密度风险的大脑麻的儿童
Marianne Lindblad Pedersen1, Johan Sebastian Ohlendorf2, Thomas Alexander Gerds2
1University Hospital Herlev, Department of Pediatrics, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.
Bone
|May 8, 2025
概括
低骨矿物质密度 (BMD) 影响了17%的脑儿童. 关键的危险因素包括较高的总运动功能分类系统分数,有限的举重活动和抗发作药物.
科学领域:
- 儿科整形外科 儿科整形外科
- 儿科神经学 儿科神经学
- 儿科内分泌学 儿科内分泌学
背景情况:
- 大脑 (CP) 是一种常见的慢性疾病,导致儿童的运动残疾.
- 低骨矿物质密度 (BMD) 是患有CP的儿童的一个重大问题,可能会增加骨折风险.
- 了解这个人群中低BMD的患病率和风险因素对于有效管理至关重要.
研究的目的:
- 确定诊断为脑性麻 (CP) 的儿童患有低骨矿物质密度 (BMD) 的患病率.
- 调查骨硬化和儿童脑膜炎的各种风险因素之间的关联.
- 确定有助于儿童CP患者骨健康下降的特定因素.
主要方法:
- 进行了一项涉及脑儿童的横截面研究.
- 数据收集包括双X射线吸收计 (DXA) 用于骨质量评估,血液测试,临床检查 (包括Tanner阶段),人体测量和体力活动评估.
- 参与者的总运动功能分类系统 (GMFCS) 评分与 BMD 相比进行了分析.
主要成果:
- 该研究包括81名患有CP的儿童,年龄为2.1-17.4岁 (中位数为9岁).
- 观察到的平均BMDz-score为-0.2,其中17%的参与者表现出低BMD.
- 较高的GMFCS得分 (p < 0.01),每天不到30分钟的举重活动 (p = 0.01),以及使用抗发作药物 (p = 0.02) 与较低的BMD有显著联系.
结论:
- 大约17%的脑儿童的骨矿物质密度较低,无论运动障碍的严重程度如何.
- 总运动功能分类系统得分,有限的承重体力活动和抗发作药物的使用与CP儿童的BMD有负面关联.
- 血清维生素D水平,性别,BMI和青春期状态在这个队列中没有发现与BMD有显著的关联.
相关概念视频
01:29Bone Disorders
3.3K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.3K
01:25Role of Vitamins in Maintaining Bone Health
3.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.1K
01:31Essential Minerals for Bone Health
3.6K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.6K