酸:甜味调节剂为癌细胞提供燃料,化瘤微环境
Jialu Bai1, Ruiling Xiao1, Decheng Jiang1
1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; Key Laboratory of Research in Pancreatic Tumor, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; State Key Laboratory of Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
瘤微环境 (TME) 中异常的酸表达促进癌症的进展和免疫抑制. 向酸为新型癌症疗法提供了一个有前途的战略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 葡萄糖生物学 葡萄糖生物学
背景情况:
- 瘤微环境 (TME) 极大地影响癌症的进展,转向免疫激活或抑制.
- 酸是具有9碳骨干的单糖,在调节TME方面发挥着重要作用.
- 对癌细胞和瘤层的异常化与瘤进展有关,包括抑制亡,增强增殖和转移.
研究的目的:
- 调查失调的酸表达在形成免疫抑制性TME中的作用.
- 探索酸有助于免疫逃生和TME调节的机制.
- 突出针对异常化在癌症治疗中的治疗潜力.
主要方法:
- 关于酸在癌症中的作用的最近研究的综述.
- 分析涉及免疫细胞上酸受体相互作用的机制.
- 对正在进行的酸向疗法的临床试验进行审查.
主要成果:
- 在TME中失调的酸表达通过减少抗瘤免疫细胞和损害它们的功能来促进免疫抑制利基.
- 酸有助于通过与免疫细胞上酸受体的相互作用来逃脱免疫.
- 几种酸向疗法正在临床试验中,显示出治疗前景.
结论:
- 异常化是瘤进展和免疫逃避的一个关键因素.
- 向酸通路为分子诊断和癌症治疗提供了重大机会.
- 通过针对异常化来重新编程TME,可能会导致创新的抗癌策略.
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