效应虽然很少见,但仍然存在
Giulia Napoli1, Simone Leggeri2, Carla Lombardi1
1Unit of Chemistry, Biochemistry and Molecular Biology, "A. Gemelli" Hospital Foundation IRCCS, Largo A. Gemelli, 8, 00168 Rome, Italy.
Clinical biochemistry
|May 8, 2025
概括
效应可能导致人体胆性淋巴激素 (β-HCG) 结果虚假低,影响像囊泡这样的诊断. 用不同套件分析样本对于准确的临床决策至关重要.
科学领域:
- 临床化学 临床化学
- 免疫测试技术 免疫测试技术
- 生殖内分泌学 生殖内分泌学
背景情况:
- 效应是免疫试验中的一个现象,在免疫试验中,高度的分析物和了抗体,导致错误的低度测量.
- 这种分析干扰可能会对诊断准确性产生重大影响,特别是在定量测试中.
研究的目的:
- 报告在测量人类胆管性腺激素 (β-HCG) 时观察到的效应的一个案例.
- 突出免疫试验干扰引起的诊断差异的可能性.
- 强调在实验室结果与临床发现相冲突时考虑分析干扰的重要性.
主要方法:
- 通过使用Atellica IM 1600分析仪在孕妇血清中测量β-HCG,确定了效应的情况.
- 患者的样本也使用Alinity-i总β-hCG套件 (Abbott) 进行了分析,以进行比较评估.
- 分析程序被修改以减轻效应,并向制造商提交了一份报告.
主要成果:
- β-HCG结果与患者的妊娠年龄 (怀孕第十三周) 不一致.
- 观察到的差异表明了效应的存在,支持了膀分子的临床诊断.
- 使用不同的诊断套件进行分析时,发现了结果的差异,强调了套件特定的分析性能.
结论:
- 实验室结果和临床表现之间的差异需要与实验室专家协商,以确定分析干扰.
- 效应可能导致误诊;在这种情况下,它有助于识别囊泡分子.
- 意识到潜在的干扰和套件间的变化对于准确的患者管理至关重要.
更多相关视频
05:22Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies
Published on: May 9, 2019
5.3K
11:30Unravelling the Function of a Bacterial Effector from a Non-cultivable Plant Pathogen Using a Yeast Two-hybrid Screen
Published on: January 20, 2017
11.4K
相关概念视频
01:53Cause and Effect
10.8K
While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
10.8K
00:52Social Proof
27.2K
Social proof is a form of persuasion based on comparison and conformity. People compare their behavior and actions to what others are doing and will change to conform to do what their peers do.
27.2K
03:26Framing Effects
7.3K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
7.3K
01:37Social Loafing
34.4K
Another way in which a group presence can affect performance is social loafing—the exertion of less effort by a person working together with a group. Social loafing occurs when our individual performance cannot be evaluated separately from the group. Thus, group performance declines on easy tasks (Karau & Williams, 1993). Essentially individual group members loaf and let other group members pick up the slack. Because each individual’s efforts cannot be evaluated,...
34.4K
01:19Impact Loading
168
Impact loading occurs when a moving object collides with a stationary structure, such as a rod with a uniform cross-sectional area fixed at one end. Under these conditions, the rod absorbs the kinetic energy from the striking object, leading to deformation and subsequent stress development. As the rod returns to its original position and reaches maximum stress, the absorbed energy, initially manifested as kinetic energy, transforms entirely into strain energy.
In cases of elastic deformation,...
In cases of elastic deformation,...
168
01:03Serial Position Effect
104
The serial position effect is a cognitive phenomenon where individuals are more likely to recall the first and last items in a list compared to those in the middle. This effect is divided into the primacy effect and the recency effect. The primacy effect is observed when the initial items in a list are remembered better. This occurs because these items are rehearsed more frequently or receive more elaborative processing, allowing them to be encoded into long-term memory more effectively. For...
104