尿金属在短期,中期和长期的变化及其最佳采样策略:对暴露分类的新型流行病学见解
Yanbing Li1, Liu Liu2, Yayuan Mei3
1Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China.
Environmental research
|May 8, 2025
概括
尿中的金属含量差异很大,因此单个样本对暴露评估不可靠. 对于和,使用2-3个样本,或为其他人使用5-10个样本,可以提高环境健康研究的准确性.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 金属对健康的影响是已知的,但单个尿样可能错误地分类暴露,因为高可变性.
- 了解尿液金属度的变化对于环境健康研究中准确的暴露评估至关重要.
- 需要最佳的采样策略和最小的样本大小,以提高对金属暴露的流行病学研究的可靠性.
研究的目的:
- 在健康成年人中评估22种尿金属在短期,中期和长期间隔中的可再生性.
- 为了确定在不同的时间框架中准确分类暴露所需的最小样本大小.
- 评估不同流行病学研究设计对提高暴露分类准确性的影响.
主要方法:
- 一项为期两年的重复测量研究从60名健康成年人收集了3,541个早晨空气 (FMV) 尿液样本,分别来自4次访问.
- 使用差异分配和类内相关系数 (ICC) 来评估金属的可重复性.
- 用替代品类别分析和四种流行病学情景来确定最小样本大小和评估研究设计.
主要成果:
- 在小便金属水平的每日显著变化被观察到在团体和个人层面.
- (Co) 和 (Zn) 的可重复性最高,仅需要2-3个样本才能准确地分类暴露.
- (As),铜 (Cu) 等金属需要5-10个样本,而 (Al), (Cr), (Sb) 和 (Se) 的复制性较差.
结论:
- 依靠单个尿样可能导致对金属暴露的错误分类;需要多个样本.
- 在流行病学研究中,具体的采样策略和适当的样本大小,因金属而异,对于准确的暴露评估至关重要.
- 结合抽样日期和间隔等时间因素的研究设计显著提高了对高可变性金属的暴露分类准确性.
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