血清25-基维生素D3与结核感染患者的氧化平衡得分之间的相关性
Yan Yong1, Li-Hong Zhou1, Sheng-Ya Yang1
1Zhejiang Tuberculosis Diagnosis and Treatment Center, Zhejiang Chinese and Western Medicine Integrated Hospital, Hangzhou, Zhejiang, China.
概括
血清25-基维生素D3 (25(OH) D3) 与结核患者的氧化平衡有关. 低于51.9nmol/L的维生素D水平显示出显著的关联,表明其在结核病治疗中的潜在作用.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 传染性疾病 传染性疾病
背景情况:
- 结核病 (TB) 与亲和抗氧化剂的不平衡有关,影响疾病的进展.
- 识别关键的氧化应激指标对于了解结核病原体至关重要.
研究的目的:
- 确定与结核病患者的氧化平衡相关的主要氧化应激指标.
- 研究血清25-基维生素D3 (25(OH) D3) 与结核病中的氧化平衡评分 (OBS) 之间的关系.
主要方法:
- 在339名结核病参与者中利用趋势回归,通用添加模型,多项式回归和值效应分析.
- 使用皮尔森和调解分析检查了血清25(OH) D3和OBS成分之间的相关性.
主要成果:
- 血清25(OH) D3是唯一独立与结核病患者的OBS相关的指标.
- 观察到一个非线性正相关性,25(OH) D3.3.的值效应为51.9nmol/L.
- 身体质量指数 (BMI) 和里波弗拉调解了25(OH) D3和OBS之间的关系.
结论:
- 血清25(OH) D3与结核病患者的氧化平衡有显著的关系.
- 维生素D状态,特别是低于51.9nmol/L的水平,可能在结核病管理中发挥作用.
- 这项研究提供了支持维生素D作为结核病辅助疗法的证据.
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