Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Meiosis I01:49

Meiosis I

191.6K
Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by...
191.6K
Cholinergic Neurons: Neurotransmission01:23

Cholinergic Neurons: Neurotransmission

2.4K
Cholinergic neurotransmission involves the synthesis and the release of acetylcholine (ACh) in order to transmit nerve impulses across the synapse. The process begins with the synthesis of acetyl CoA, a precursor for ACh, from ATP, acetate, and coenzyme A in the mitochondria. Choline, another vital precursor, is transported inside the neuron through choline transporters, including high-affinity choline transporter CHT1, low-affinity choline transporter CTL1, and lower-affinity choline...
2.4K
Chemical Synapses01:26

Chemical Synapses

8.6K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
8.6K
Karyotyping01:17

Karyotyping

55.4K
Overview
55.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Frequency of mixed neuropathologies in individuals with down syndrome with and without Alzheimer's dementia.

Acta neuropathologica·2026
Same author

Psychometric criteria for superior cognitive performance in very old adults.

Journal of Alzheimer's disease : JAD·2026
Same author

Cerebrospinal fluid and frontal cortex TMPRSS2 and ACE2 protein levels differ in Down syndrome and Alzheimer's disease.

Acta neuropathologica communications·2026
Same author

Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer's Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Pretangle tau pathology accrual in the default mode network during the progression of Alzheimer's disease.

Molecular neurodegeneration advances·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

相关实验视频

Updated: May 12, 2025

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
06:38

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

264

唐氏综合征中的胆类系统.

Elliott J Mufson1, Sylvia E Perez2

  • 1Department of Translational Neuroscience, St. Joseph's Hospital and Medical Center, Barrow Neurological Institute, Phoenix, AZ, United States; Department of Neurology, St. Joseph's Hospital and Medical Center, Barrow Neurological Institute, Phoenix, AZ, United States.

Handbook of clinical neurology
|May 8, 2025
PubMed
概括

胆固醇神经元在唐氏综合征 (DS) 中退化,神经营养因素和病理有助于这种下降. 确定了痴呆症的生物标志物和胆固醇系统的治疗点.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的疾病生物标志物 生物标志物胆固醇作用的 胆固醇作用发展发展发展 发展发展唐氏综合征是什么意思 唐氏综合征毒品的目标是毒品.基因 基因 基因 基因神经营养受体的神经营养受体产后 产后 的 产后在产前,产前生育.

更多相关视频

Measuring Glucose Uptake in Drosophila Models of TDP-43 Proteinopathy
07:07

Measuring Glucose Uptake in Drosophila Models of TDP-43 Proteinopathy

Published on: August 3, 2021

2.7K
A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

Published on: October 6, 2015

19.4K

相关实验视频

Last Updated: May 12, 2025

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
06:38

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

264
Measuring Glucose Uptake in Drosophila Models of TDP-43 Proteinopathy
07:07

Measuring Glucose Uptake in Drosophila Models of TDP-43 Proteinopathy

Published on: August 3, 2021

2.7K
A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

Published on: October 6, 2015

19.4K

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 遗传学 是一个
  • 病理学 病理学 病理学

背景情况:

  • 唐氏综合症 (DS) 涉及胆固醇基底前脑 (CBF) 投射神经元和条状胆固醇内部神经元的退化.
  • 在DS中,这些独特的胆性表型的神经病理生物学尚未完全理解.
  • 本综述检查了胆固醇,神经营养和细胞死亡因子的变化,以及DS中tau和amyloid病理.

研究的目的:

  • 综述和总结影响唐氏综合征中胆固醇神经元的神经病理变化.
  • 确定潜在的生物标志物,以区分患有痴呆症和没有痴呆症的个人.
  • 探索缓解DS中胆性神经退行症的治疗点.

主要方法:

  • 对唐氏综合征中胆固醇系统变化的现有文献的综述.
  • 对神经变因子,细胞死亡途径,病理和DS中的粉样蛋白病变的分析.
  • 研究潜在的生物标志物和治疗策略.

主要成果:

  • 三症发育中的胆固醇系统是稳定的,但神经营养受体在DS中受到损害.
  • 无论是CBF还是条状胆固醇神经元,在患有DS的成年人和老年人中都会出现严重的退化.
  • 胆固醇条状神经元在患有DS的成年人中呈现变质,而这两种细胞类型在老年人中都表现出病理.
  • 亲NGF,NGF代谢物和神经元基因的变化可能作为DS痴呆症的生物标志物.

结论:

  • 胆性神经退行是唐氏综合征的一个重要特征,由受损的神经营养支持和病理加剧.
  • 血和脑脊液中的生物标志物,包括proNGF和特定的神经元基因,显示出区分痴呆症在DS中的状态的希望.
  • 向胆固醇通路,神经营养因子 (如NGF及其受体) 和特定基因通路,为减缓DS神经退行提供了潜在的治疗途径,这对阿尔茨海默病 (AD) 有影响.