90岁以上的主观记忆抱怨与认知和发病痴呆症风险有关:90岁以上的研究
Zarui A Melikyan1, Colette Aguirre2, Zeinah Al-Darsani2
1Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
International psychogeriatrics
|May 8, 2025
概括
90岁以上个体的主观记忆问题 (SMC) 与认知能力低下有关,并使未来痴呆的风险增加一倍. 一个简单的SMC问题可能有助于识别那些处于危险之中的人.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 认知老龄化 认知老龄化
背景情况:
- 主观记忆投诉 (SMC) 及其与认知衰退和痴呆风险的关联在90岁及以上的个人中尚不清楚.
- 最年长的老年人群经历了认知障碍的高发病率和流行率,这使得这个人口群体对痴呆症研究至关重要.
研究的目的:
- 为了确定老年人口中SMC的频率.
- 检查SMC和认知测试表现之间的横截面关系.
- 为了比较SMC的预测能力,迷你精神状态检查 (MMSE) 和这种年龄组中发生痴呆症的认知诊断.
主要方法:
- 横截面分析包括893名没有基线痴呆症的参与者 (平均年龄93岁),评估SMC,MMSE,其他认知测试和认知诊断.
- 纵向分析涉及一个具有后续认知诊断的子集.
- 线性回归探索了横截面关联; 考克斯回归模型评估了痴呆风险预测,与对应指数 (C指数) 进行模型性能比较.
主要成果:
- 43%的参与者报告了SMC,这与记忆,语言和执行功能的得分较低有关.
- 在3.5年的时间里,789名参与者中有325人患上了痴呆症.
- SMC使发病痴呆的风险增加了一倍 (HR=2.16) 并预测痴呆风险与MMSE相比,但效果不如认知诊断.
结论:
- 关于主观记忆投诉的单个问题可以是一个有价值的工具.
- SMC可能有助于识别具有认知障碍或痴呆风险较高的老年人群中的个人.
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