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Updated: May 12, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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在特定细胞群中,内在/近端细胞表面标记物逻辑启动的细胞外向蛋白质降解

Yafeng Wang1, Guiquan Zhang2, Ping Rong3

  • 1Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210008, China.

Molecular therapy : the journal of the American Society of Gene Therapy
|May 9, 2025
PubMed
概括

研究人员开发了针对蛋白质降解的新分子工具,提高了潜在新疗法的精度. 这些工具改善了药物输送,并且在治疗诸如狼之类的自身免疫性疾病方面表现有前途.

关键词:
两种特异性抗体的抗体这是一种内细胞降解剂.细胞外向蛋白质降解的向蛋白质降解逻辑大门的逻辑大门.精选的内细胞载体向的奇米拉.准的具体性是针对性的.

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