向性鼻道输送带有抗结核药物加载的化抗结核药物纳米嵌入微粒用于中枢神经系统中菌消除
Krishna Jadhav1, Agrim Jhilta1, Raghuraj Singh1
1Institute of Nano Science and Technology (INST), Knowledge City, Sector-81, SAS Nagar, Mohali 140306, Punjab, India.
Molecular pharmaceutics
|May 9, 2025
概括
纳米配方抗结核药物 (ATD) 通过纳米嵌入微粒 (NEM) 的鼻内输送有效绕过血脑屏障. 这种新的方法在中枢神经系统结核病 (CNS-TB) 鼠标模型中显著降低了细菌负载.
科学领域:
- 纳米技术和药物输送
- 传染性疾病 传染性疾病
- 神经科学是一个神经科学.
背景情况:
- 中枢神经系统结核病 (CNS-TB) 是一种严重的肺外结核病,死亡率高,神经功能受损.
- 由于血脑屏障 (BBB),目前的治疗方法在脑脊液中达到足够的药物度方面面临挑战.
- 鼻腔途径提供了直接向大脑输送药物的潜在策略,绕过BBB.
研究的目的:
- 开发和评估装载有抗结核药物 (ATD) 的酸聚乳-同-甘油酸 (PLGA) 纳米粒子 (CS-PLGA NPs),用于鼻内输送.
- 通过喷雾干燥,将这些纳米颗粒配制成动态微型纳米嵌入微粒 (NEM).
- 在中枢神经系统结核病的小鼠模型中评估ATD-NEMs配方的疗效.
主要方法:
- 在CS-PLGA的NP中含有异化 (INH) 和利芬素 (RIF).
- 喷雾干燥被用来从药物装载的NP中创建纳米嵌入微粒 (NEM).
- 使用鼻隔膜单层进行了体外透研究,并在结核病感染的小鼠身上进行了体内疗效研究.
主要成果:
- 与自由的ATD相比,ATD-NEMs配方在鼻腔隔膜单层中显著增强了透.
- 在结核病感染的小鼠中,ATD-NEMs的鼻内注射导致大脑中的细菌殖民地形成单位 (CFU) 显著减少.
- 组织病理学分析支持通过CFU减少观察到的治疗疗效.
结论:
- 鼻内注射ATD-NEM是一种可行且有效的策略,用于治疗中枢神经系统结核病.
- 该NEM配方显示了改善整个BBB的药物输送和减少大脑炎症的潜力.
- 这种方法有望提高中枢神经系统结核病患者的治疗结果.
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