中非共和国的罗塔病毒流行率和基因型,2011-2021年
Joël W Dote1, Virginie Banga Mingo2, Jean Fandema2
1Institut Pasteur de Bangui, BP 923, Bangui, Central African Republic. joel.dote@pasteur-bangui.cf.
BMC infectious diseases
|May 9, 2025
概括
罗塔病毒胃肠炎是撒哈拉以南非洲的主要婴儿杀手. 这项研究确定了2011-2021年中非共和国常见的轮状病毒菌株 (G1P[8]和G1P[6]),提供了关键的疫苗前数据.
科学领域:
- 病毒学 病毒学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 罗塔病毒胃肠炎对婴儿死亡率构成重大威胁,特别是在撒哈拉以南非洲.
- 中非共和国 (CAR) 的轮状病毒胃肠炎的哨戒监测始于2011年.
- 这项研究旨在确定2011年至2021年期间中非共和国的轮状病毒负担和流通的轮状病毒菌株.
研究的目的:
- 评估罗塔病毒胃肠炎在中非共和国幼儿中的流行率.
- 为了在十年内确定在中非共和国流通的特定轮状病毒基因型.
- 在潜在的疫苗引入之前建立基线轮状病毒基因型数据.
主要方法:
- 便样本从5岁以下的腹儿童在中非共和国班吉的一个哨兵站点收集.
- 样本使用酶免疫试验 (EIA) 测试轮状病毒A组抗原.
- 来自阳性样本的RNA进行了半嵌套RT-PCR,用于VP7和VP4基因基因定型.
主要成果:
- 收集了1800多个便样本,轮状病毒阳性率为46%.
- 最常见的VP7基因型是G1 (35.4%) 和G2 (26.6%).
- 主要的VP4基因型是P[6] (42.7%) 和P[8] (35.6%),其中G1P[8]和G1P[6]是最常见的组合.
结论:
- 这项研究提供了长达十年的罗塔病毒基因型流行率在CAR的概述.
- 这些发现为轮状病毒胃肠炎监测提供了重要的疫苗前基线数据.
- 了解流通的菌株对于为该地区的公共卫生战略和疫苗疗效提供信息至关重要.
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