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肠道微生物群的改变与儿童高血压有关
Jiahong Sun1,2, Liu Yang3, Chuanwei Ma4
1Department of Preventive Medicine, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, China.
BMC microbiology
|May 9, 2025
概括
患有高血压 (HTN) 的儿童表现出肠道微生物群多样性的减少和特定细菌系的改变. 这些肠道微生物群的变化可能有助于早期发现儿童HTN.
科学领域:
- 微生物组研究的研究.
- 儿科心脏病学 儿科心脏病学
- 肠道健康 肠道健康
背景情况:
- 儿童高血压 (HTN) 是一个越来越令人担忧的问题.
- 肠道微生物群干扰与儿童HTN之间的联系尚不清楚.
研究的目的:
- 调查带有和没有HTN的儿童之间的肠道微生物群组成和多样性的差异.
- 确定潜在的肠道微生物群生物标志物,用于儿科早期检测HTN.
主要方法:
- 来自102名儿童的便样本的16S核糖体RNA基因测序 (51名患有HTN,51名血压正常).
- 对微生物种群的丰富性和多样性的分析.
- 统计分析包括FDR调整,ROC,NRI和IDI.
主要成果:
- 患有HTN的儿童表现出明显减少的肠道微生物群多样性.
- 在患有HTN的儿童中,特定的属 (例如,Blautia,Coprococcus,norank_f__Lachnospiraceae) 的数量较少.
- 肠道微生物群的概况,特别是Lachnospiraceae和Dorea,改善了基于BMI的HTN差异化.
结论:
- 肠道微生物群的改变与儿童高血压有关.
- 肠道微生物群生物标志物对儿童HTN的早期识别和诊断有前途.
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