第一次躁狂发作中的个体级大脑现象型:大脑形态和BrainAGE的规范建模
Kevin Yu1, Ruiyang Ge1, Yuetong Yu1
1Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
BJPsych open
|May 9, 2025
概括
第一发疯病 (FEM) 患者显示正常的区域大脑结构,但微妙的全球大脑衰老延迟. 这些大脑衰老模式可能会随着早期双相情感障碍发病年龄而变化.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 大脑形态测量 - - 大脑形态测量
背景情况:
- 双极性障碍与大脑变化有关,特别是在慢性病例中.
- 这项研究调查了第一发疯病 (FEM) 的神经解剖学差异,这是该疾病的早期阶段.
研究的目的:
- 量化FEM患者从规范性大脑形态学偏差的数量.
- 评估与年龄相关的大脑变化及其与早期双相情感障碍临床特征的关系.
主要方法:
- 通过使用预训练模型,分析了83名FEM患者和61名健康对照者的结构性脑图像.
- 计算了规范偏差z-score,全球大脑年龄差距 (G-brainAGE) 和本地大脑年龄差距 (L-brainAGE).
- 机器学习模型评估了形态数据对临床结果和诊断的预测价值.
主要成果:
- 在FEM患者和健康对照组中,区域大脑形态学偏差的比例相似.
- 大脑形态测量没有显著预测症状严重程度,智商或诊断.
- 在FEM中平均G-brainAGE为-1.04年,与发病年龄负相关;L-brainAGE在各组之间没有差异.
结论:
- 在FEM中,区域大脑形态测量和局部大脑衰老与规范范围保持一致,这表明在早期双相情感障碍中存在最小的异常.
- 在FEM中微妙的全球大脑衰老延迟可能与发病年龄有关,这需要进一步调查.
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