针对可切除食道腺癌的不断发展的治疗方法
Kelsey A Klute1, Manish A Shah2
1Department of Medicine, University of Nebraska Medical Center, Omaha, NE.
概括
仅进行手术切除就不足以治疗局部发达的食道腺癌. 包括化疗和免疫疗法在内的新型外科手术治疗正在改善生存率,但耐药性仍然是一个挑战.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 手术瘤学手术瘤学
背景情况:
- 手术切除是局部食道腺癌的主要治疗方法.
- 由于复发率高,单独切除对局部晚期疾病是不够的.
- 目前的多式联运战略已经提高了生存率,但仍然存在重大未满足的需求.
研究的目的:
- 对食道腺癌的基于证据的和新兴的术后策略进行审查.
- 探索适应风险的方法来个性化外科手术治疗.
- 在局部晚期食道腺癌中解决对细胞毒性疗法的耐药性.
主要方法:
- 对食道腺癌的术后治疗方法的当前文献的综述.
- 对各种治疗方式的生存数据的分析.
- 讨论新的治疗策略和风险分层.
主要成果:
- 术后化学疗法,化学辐射疗法和免疫检查点封锁改善了生存率.
- 大约50%的局部晚期疾病患者仍会出现复发.
- 对细胞毒性治疗的耐药性需要开发新的治疗方法.
结论:
- 多种模式的周围手术治疗对于局部晚期食道腺癌至关重要.
- 需要进一步的研究来克服治疗耐药性.
- 个性化,与风险相适应的外科手术期间策略有望改善患者的治疗结果.
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