骨空填充材料用于增强碎骨折:全面审查
S-Sina Mohammadi1, Sunjeev S Phull2, B Sonny Bal3
1Missouri University of Science and Technology, Department of Chemical and Biochemical Engineering, 1101 N State St, Rolla, MO, 65409, US. S.mohammadi@mst.edu.
Journal of orthopaedic surgery and research
|May 9, 2025
概括
管理碎骨折需要有效的骨空填充剂. 本综述考察了移植和合成材料,强调了需要改进的生物材料,将强度和生物活性结合起来,以获得更好的骨科结果.
科学领域:
- 整形外科手术 整形外科手术
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
背景情况:
- 压缩性骨折在骨科手术中带来了重大挑战.
- 有效的管理需要骨空隙填充剂来增强固定和促进再生.
- 目前的增强材料具有影响治疗疗效的限制.
研究的目的:
- 审查骨空填充剂在碎骨折管理中的应用.
- 为了比较各种骨腔填充材料的有效性和局限性.
- 确定骨折修复生物材料开发的进展和未来方向.
主要方法:
- 关于骨腔填充材料的文献综述.
- 自体移植,异体移植,聚甲基甲酸 (PMMA) 和合成骨替代品的分析.
- 评估最近的生物材料改造和创新.
主要成果:
- 自体移植提供优越的骨质生成,但有捐赠者部位问题.
- 所有移植存在免疫性风险.
- PMMA提供稳定性,但有细胞毒性问题.
- 合成骨头替代品,如酸陶和生物活性玻璃,显示出有前途,但具有机械限制.
- 最近的进展集中在复合材料和离子合生物陶上.
结论:
- 对于破碎骨折,没有单一的理想骨空填充剂存在.
- 在将结构完整性与生物活性相结合的材料中仍然存在差距.
- 未来的研究应该专注于开发承载性,生物活性材料,以优化骨折管理.
更多相关视频
08:41Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
8.2K
07:35Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
Published on: April 11, 2012
17.4K
相关概念视频
Fractures: Bone Repair
2.8K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
2.8K
The Bone Matrix
2.9K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
2.9K
Additives and Fillers in Concrete
66
Additives and fillers are integral to enhancing the properties of concrete. Pozzolans and blast-furnace slag are additives or admixtures due to their reactions with calcium hydroxide released during cement hydration. Fillers, which are finely ground and similar in fineness to Portland cement, improve concrete attributes such as workability density, and reduce capillary bleeding or cracking. Some fillers possess hydraulic properties or participate in benign reactions within the cement paste.
The...
The...
66
Spongy Bone
3.9K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
3.9K
Bone Remodeling
38.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.0K
