病例报告:在一个健康的孩子身上,由burkholderia multivorans引起的宫支性淋巴腺炎
Bei-Bei Niu1, Jing-Jing Xu1, Ji-An Li2
1Department of Plastic and Burn Surgery, Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital), Jingshi Street 23976, Jinan, 250000, Shandong, China.
BMC infectious diseases
|May 9, 2025
概括
伯克霍尔德里亚多 (Burkholderia multivorans,简称BM) 是儿科宫淋巴腺炎的一种罕见病因. 甲基因组测序在患有持续部胀的儿童中发现了BM,导致了抗生素和伤口护理的成功治疗.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 儿童的宫支性淋巴腺炎通常源于金黄色葡萄球菌或Streptococcus pyogenes.
- 涉及Burkholderia multivorans (BM) 的病例不常见,并存在非特异性症状,使诊断复杂化.
研究的目的:
- 突出Burkholderia multivorans (BM) 作为小儿宫淋巴腺炎的潜在病原体.
- 强调对罕见病原体的先进诊断方法的重要性.
主要方法:
- 一个5岁男孩患有持续性宫淋巴腺炎的病例报告.
- 通过手术活检,病理检查和元基因组下一代测序 (mNGS) 证实了诊断.
- 治疗包括trimethoprim-sulfamethoxazole,meropenem和真空辅助关闭 (VAC) 疗法.
主要成果:
- 基因组下一代测序 (mNGS) 确定了Burkholderia multivorans (BM) 作为致病剂.
- 患者实现了完整的伤口愈合,并且在治疗后没有出现复发.
- 最初的抗生素治疗是无效的,强调了需要准确的病原体识别.
结论:
- 在儿科宫淋巴腺炎中应考虑Burkholderia multivorans (BM),特别是当没有识别出常见病原体时.
- 通过像mNGS这样的先进技术进行早期和准确的诊断对于有效的治疗和改善患者结果至关重要.
相关概念视频
01:25Cholera
Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
01:20Chickenpox
Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
01:17Poliomyelitis
Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:22Bacterial Meningitis I: Introduction
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
01:26Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...