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Updated: May 12, 2025

Using the E1A Minigene Tool to Study mRNA Splicing Changes
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对161个序列变化的TP53小基因分析提供了空间约束和调控因素对变异诱导的拼接影响作用的证据

Daffodil M Canson1, Inés Llinares-Burguet2, Cristina Fortuno1

  • 1Population Health Program, QIMR Berghofer, Herston, QLD, 4006, Australia.

NPJ genomic medicine
|May 9, 2025
PubMed
概括

在TP53拼接调节元件 (SREs) 中的干扰可以导致显著的异常转录表达. 影响多个SRE的删除严重影响拼接,可能影响癌症倾向和瘤发生.

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