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Updated: Jun 17, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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针对RIPK3的强效和选择性抑制剂的基于结构的设计,以消除在体外的目标毒性

Haixia Su1,2, Guofeng Chen3, Hang Xie4

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Shanghai, 201203, China. suhaixia1@simm.ac.cn.

Nature communications
|May 9, 2025
PubMed
概括

新的RIPK3抑制剂在不诱导亡的情况下阻止了亡. 这些由特定突变启发的LK系列化合物表现出高激酶选择性,并以非活性形式稳定RIPK3以实现更安全的治疗开发.

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Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...