在妇科腹腔镜手术后预防恶心和吐的promethazine:一个随机对照试验
Liu Ruijuan1, Zhang Jiqiang2, Bi Ruirui3
1Department of Anesthesiology, Gansu Provincial Hospital, Lanzhou, China.
Scientific reports
|May 9, 2025
概括
在妇科 laparoscopic 手术患者的术后恶心和吐 (PONV) 显著减少了手术前的 promethazine. 这种预防方法提高了患者的满意度,并证明了良好的安全性.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 手术后恶心和吐 (PONV) 显著影响患者的康复,特别是在腹腔镜手术后.
- 在接受腹腔镜手术的女性患者中,PONV的发病率很高,如果没有预防性治疗,风险很大 (高达80%).
- 目前用于PONV预防和管理的策略仍然不理想,需要进一步研究.
研究的目的:
- 评估手术前预防性普罗梅他辛在减少PONV的发病率和严重性的有效性.
- 评估普罗马对妇科后腹腔镜手术患者满意度和安全性概况的影响.
主要方法:
- 一项前性,随机,双盲,单中心研究,涉及100名接受妇科腹腔镜手术的女性患者.
- 在麻醉诱导之前,患者接受了静脉注射普罗马 (6.25毫克) 或液安慰剂.
- 所有患者都接受了标准化的术后止痛和甲托克洛普拉米德输液;在72小时内评估了PONV发病率和严重程度.
主要成果:
- 普罗米塔辛在手术后72小时内显著降低了PONV的整体发病率和严重程度 (P=0.026).
- 早期术后恶心 (前6小时) 和24小时内整体恶心/吐在普罗梅他辛组明显较低 (P<0.05).
- 患者满意度在普罗梅他组显著更高 (P=0.002),具有有利的安全性和最小的不良反应.
结论:
- 术前预防性普罗马素在接受妇科腹腔镜手术的患者中有效降低PONV发病率和严重程度.
- 这种干预措施提高了患者的满意度,并显示出良好的安全性,使其成为PONV管理策略的宝贵补充.
- 进一步的研究可能会探索最佳剂量和更广泛的应用Prometazine用于PONV预防.
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