在美国成年人中,乙型肝炎病毒感染和抑郁症的解决之间的关联:一个横截面研究
Zihan Qin1, Yizhuo Liu1, Yifei Liu1
1Hebei Medical University, Shijiazhuang, 050017, China.
Scientific reports
|May 9, 2025
概括
已解决的乙型肝炎病毒 (HBV) 感染与更高的抑郁症风险有关. 这项研究发现了显著的关联,这表明对已解决HBV感染的个体提供心理支持.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 心理健康研究 心理健康研究
背景情况:
- 乙型肝炎病毒 (HBV) 感染构成了全球健康挑战,可能对心理健康产生影响,包括抑郁症.
- 已解决的HBV感染,通常被认为不那么严重,与抑郁症有着不清楚的关联.
- 了解这种联系对于全面的患者护理至关重要.
研究的目的:
- 调查乙型肝炎病毒感染和抑郁症之间解决的关联.
- 分析来自大量,代表性的美国成年人口的数据.
- 为在过去感染HBV的人群中提供有针对性的心理健康支持的证据.
主要方法:
- 对国家健康和营养检查调查 (NHANES) 数据 (2005-2018) 的横截面分析,其中包括20655名成年人.
- 定义了 HBV 感染的 HBsAg 阴性和 HBcAb 阳性.
- 使用倾向分数匹配 (PSM) 和治疗权重的逆概率 (IPTW) 来控制混因素并通过PHQ-9分数评估抑郁症.
主要成果:
- 1,551名参与者 (7.5%) 的HBV感染已经消失.
- 与没有 (8.5%) 相比,患有 HBV 感染的患者 (10.6%) 患有抑郁症的患病率更高.
- 两种PSM (OR=1.40) 和IPTW (OR=1.48) 分析都显示出 HBV 感染和抑郁症 (p<0.001) 之间存在显著的积极关联.
结论:
- 已解决的乙型肝炎病毒感染与抑郁症的可能性增加有显著的关联.
- 这一发现突显了慢性病毒感染和心理健康之间的复杂相互作用.
- 建议对已解决HBV感染的个体进行心理监测和支持,强调需要对潜在机制进行进一步研究.
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