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[68Ga]-DOTATOC PET/CT和清细胞细胞癌转移:简单的假阳性或潜在的分期成像?

Nicolas Jacquet-Francillon^1,2, Sibel Isal¹, Isabelle Morelec¹

¹Department of Nuclear Medicine, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon.

Clinical nuclear medicine

|May 9, 2025

概括

转移的清晰细胞细胞癌可以模仿胰腺和肺部的神经内分泌瘤 (NETs). [68Ga]-DOTATOC PET/CT扫描显示吸收率高,但活检证实了清晰细胞细胞癌转移.

科学领域:

在瘤学瘤学.
核医学就是核医学.
病理学病理学病理学

背景情况:

清细胞细胞癌 (ccRCC) 是主要的癌亚型.
常见的ccRCC转移部位包括肺和胰腺,它们与经常涉及神经内分泌瘤 (NETs) 的部位重叠.
NETs 经常表现出低氧葡萄糖 (FDG) 热度,使诊断成像复杂化.

研究的目的:

介绍两个病例,其中胰腺和肺病变,最初怀疑是基于成像的NET,最终被诊断为ccRCC转移.
要突出ccRCC转移模仿NETs所带来的诊断挑战,特别是在FDG-avid成像中.

主要方法:

两名患有ccRCC病史的患者病例报告,呈现胰腺和肺病变.
使用[68Ga]-DOTATOC正子发射断层扫描/计算机断层扫描 ([68Ga]-DOTATOC PET/CT) 进行成像.
进行了组织病理学活检以确定确诊.

主要成果:

两位患者在胰腺和肺部都有病变,可疑为NETs.
[68Ga]-DOTATOC PET/CT在这些病变中显示出强烈的标记物吸收.
活检证实病变是清细胞细胞癌的转移,而不是NET.

结论:

转移性ccRCC可以呈现出模仿NET的成像特征,特别是在胰腺和肺部等FDG热情的位置.
诊断成像,包括基于体静止素受体的PET/CT,可能会显示ccRCC转移的高吸收率,需要组织病理学确认.
对这种潜在模仿的认识对于在有ccRCC病史的患者中进行准确的诊断和治疗规划至关重要.

关键词:

清细胞脏细胞癌.在 DOTATOC 上,你会发现网络网络网络网络网络在这里,PET是PET.聚乙烯/聚乙烯/聚乙烯

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