尿中含量与美国成年人胆结石病增加之间的关联
Zhaowei Wu1, Shiming Jiang1, Jinzhi Li1
1Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Medical College Street, Yuzhong District, Chongqing, 404100, China.
Scientific reports
|May 9, 2025
概括
暴露于重金属,特别是,与美国成年人的胆结石患病率有关. 高尿水平显著增加了胆结石形成的风险,特别是在某些人群中.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 胃肠病学 胃肠病学
背景情况:
- 暴露于重金属是一种已知的健康风险.
- 重金属对胆结石患病率的具体影响尚不清楚.
- 了解导致胆结石的环境因素对于公众健康至关重要.
研究的目的:
- 调查重金属度与美国成年人胆结石患病率之间的关联.
- 为了确定有助于胆结石形成的特定重金属.
- 探索改变这种关系的人口和生活方式因素.
主要方法:
- 利用多变量逻辑回归来识别独立的风险因素.
- 采用加权量子素总和 (WQS) 回归来评估重金属混合物.
- 应用机器学习模型 (XGBoost) 和SHAP用于预测建模和变量重要性.
主要成果:
- 尿液中的度成为胆结石的独立风险因素.
- 较高的含量与胆结石形成的风险显著增加有关.
- 与胆结石的关联在年轻人,男性,特定种族,吸烟者和饮酒者中明显.
结论:
- 长期的慢性暴露被确定为胆结石患病率的重要风险因素.
- 尿中的是胆结石形成的关键预测因素.
- 这些发现强调了监测和减轻暴露对于预防胆结石的重要性.
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