基于vonoprazan的疗法与埃及Helicobacter pylori感染管理的标准治疗方案相比:一个开放的随机对照试验
Yumna M Shekeban1, Noha A Hamdy2, Doaa A Header3
1Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
新型的H. pylori治疗方法,包括诺普拉桑双重和三重疗法,显示根除率低于最佳水平. 需要进一步优化和新的疗法来对抗抗生素耐药性增加,并提高H. pylori治疗疗效.
科学领域:
- 胃肠病学和传染病学
- 药理学和治疗学 药理学和治疗学
背景情况:
- 在H. pylori的抗生素耐药性需要新的治疗策略.
- 现有的H. pylori根除方案需要定期评估有效性和安全性.
研究的目的:
- 为了评估vonoprazan双疗法 (VDT) 和vonoprazan三疗法 (VTT) 与标准三疗法 (STT) 的疗效,安全性和合规性,用于H. pylori根除.
- 调查影响遵守,治疗反应和症状严重程度的因素.
主要方法:
- 一个临床试验比较STT,VDT (vonoprazan + amoxicillin/clavulanate) 和VTT (vonoprazan + amoxicillin/clavulanate + clarithromycin) 在14天的时间里.
- 每个协议的分析被用来确定根除率.
- 研究了影响遵守,治疗反应和症状严重程度的因素.
主要成果:
- 在所有组中,根除率都低于最佳:STT (70%),VDT (76.2%) 和VTT (79.2%).
- VDT显示出比STT和VTT更好的安全概况,在治愈率上没有显著差异.
- 两组之间没有观察到治疗遵从性的显著差异.
结论:
- 目前的H. pylori治疗方案,包括VDT和VTT,表现出低于最佳的疗效,突出了优化剂量和新方法的需要.
- 需要进行进一步的研究,以开发具有更高根除率的H. pylori治疗方法,以应对日益增长的抗生素耐药性.
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