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在一项1期临床试验中,用于二次进展性多发性硬化症患者的胎盘衍生性介质干细胞细胞疗法

Ameneh Shokati^1,2,3, Mohsen Nikbakht^4,5, Mohammad Ali Sahraian²

¹Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Scientific reports

|May 9, 2025

概括

胎盘衍生介质干细胞 (PLMSCs) 显示出治疗二级渐进性多发性硬化症 (SPMS) 的前景. 这项研究发现PLMSC治疗是安全和可行的,患者经历了临床和免疫学上的改善.

科学领域:

免疫学免疫学免疫学
神经科学是一个神经科学.
再生医学是一种再生医学.

背景情况:

像多发性硬化症 (MS) 这样的自身免疫性疾病的特征是炎症.
介酶干细胞 (MSCs) 具有免疫调节特性,有利于治疗炎症疾病.
胎盘衍生MSCs (PLMSCs) 正在探索它们在MS中的治疗潜力.

研究的目的:

评估胎盘衍生MSCs (PLMSCs) 的安全性和可行性,用于患有二次进展性多发性硬化症 (SPMS) 的患者.
在SPMS中探索PLMSC移植的临床,成像和免疫效应.

主要方法:

一个涉及五名SPMS参与者的第一阶段试验.
在六个月内对安全性和耐受性进行不良事件的监测.
评估临床 (EDSS),认知,心理,成像 (DTI,fMRI) 和免疫 (细胞因子,B细胞标记物) 的结果.

主要成果:

PLMSC移植是安全的,耐受性很好,只有轻微的不良事件 (头痛).
在EDSS得分,认知功能和DTI指标 (RD) 中观察到显著改善.
fMRI显示大脑连接性得到改善. 在免疫学上,B细胞标记物减少,IL-10增加,以及减少的促炎细胞因子.

结论:

胎盘衍生的MSC移植对于SPMS患者来说是安全的和可行的.
初步数据表明潜在的临床和免疫学益处,需要进一步调查.
需要进行更大规模的II期试验来确认疗效和治疗潜力.

关键词:

大脑绘制地图.细胞疗法是一种细胞疗法.认知和心理评估.扩散张力成像的成像方法多发性硬化症是多发性硬化症.从胎盘衍生出的介质细胞干细胞.

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