控制产前甲状腺查研究III:孕期甲状腺状况对大脑微观结构的影响
Carolyn B McNabb1, Anna Scholz1,2, Laura Bloomfield1
1Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
概括
在怀孕期间,母亲的妊娠时甲状腺功能 (SGTF) 与青少年大脑白质微观结构的改变有关. 早期的Levothyroxine治疗可以逆转这些影响,支持更好的神经发育结果.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 发展生物学 发展生物学
背景情况:
- 怀孕期间母亲甲状腺功能障碍对胎儿神经发育构成风险.
- 孕期甲状腺功能 (SGTF) 对青少年大脑微观结构的影响在很大程度上是未知的.
- 了解这些影响对于确定潜在干预措施至关重要.
研究的目的:
- 调查SGTF与青少年白质微观结构之间的关联.
- 为了确定在怀孕期间母亲补充levothyroxine是否会影响青少年的大脑发育.
- 探索母亲甲状腺激素水平与大脑微观结构之间的相关性.
主要方法:
- 控制产前甲状腺查 (CATS) 研究使用磁共振成像 (MRI),包括扩散MRI和定量磁化转移 (qMT) 成像.
- 分析了75名11至16岁的儿童,他们的妊娠时甲状腺功能不同 (未接受治疗的SGTF,正常的GTF,接受治疗的SGTF).
- 评估了白质道的微观结构完整性.
主要成果:
- 与正常的妊娠甲状腺功能相比,未经治疗的SGTF与下纵向囊中的轴突完整性降低显著相关.
- 这种白质微观结构的改变在母亲患有SGTF的青少年中观察到.
- 在多次比较纠正后,对二次结果没有发现任何显著的关联.
结论:
- 不理想的妊娠甲状腺功能与青少年白质微观结构的特定变化有关.
- 怀孕期间的Levothyroxine治疗可以减轻或逆转这些微观结构变化.
- 这些发现强调了管理母亲甲状腺功能对于儿童神经发育最佳性的重要性.
关键词:
甲状腺是什么?甲状腺是什么?注意力缺陷多动性障碍注意力缺陷多动性障碍扩散磁力共振成像 (MRI) 扩散磁共振成像技术的使用骨髓蛋白是什么意思 骨髓蛋白是什么意思怀孕 怀孕 怀孕 怀孕 怀孕定量的MRI是指MRI的数量.更多相关视频
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