液体活检在区分肺癌与良性肺结节中的应用 (综述)
Mingcheng Peng1, Jun Gong2, Taixue An3
1Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.
International journal of molecular medicine
|May 9, 2025
概括
准确诊断肺结节是早期肺癌检测的关键. 液体活检提供了一种有前途的非侵入性方法,使用循环生物标志物改善患者的治疗结果.
科学领域:
- 肺部医学 肺部医学
- 在瘤学瘤学.
- 生物标志物发现发现
背景情况:
- 区分恶性和良性肺结节,特别是小或碎玻璃结节,对于有效的肺癌治疗和患者生存至关重要.
- 像成像和活检这样的当前诊断方法有局限性,导致需要替代方法.
- 了解瘤生物学导致了循环生物标志物的开发,用于监测肺癌治疗.
研究的目的:
- 提供当前肺结节诊断的全面审查.
- 为了突出非侵入性液体活检技术在肺癌的进步.
- 讨论循环生物标志物在肺癌管理中的潜力.
主要方法:
- 关于肺结节诊断的当前文献的综述.
- 探索液体活检技术的进展.
- 分析各种循环生物标志物,包括细胞外囊泡,瘤培养血小板,非编码RNA,循环瘤DNA和循环抗体.
主要成果:
- 液体活检成为传统诊断方法的可行的非侵入性替代方案.
- 各种循环生物标志物显示出早期检测,监测治疗反应和肺癌疗效的潜力.
- 最近的进展为诊断和管理肺结节提供了新的途径.
结论:
- 液体活检技术在肺结节诊断方面取得了重大进展.
- 循环生物标志物对个性化肺癌管理具有很大的前景.
- 对液体活检的进一步研究对于临床转化和改善患者护理至关重要.
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