细颗粒物与中年和老年人的执行功能较低有关:心脏代谢疾病作为调解者
Sara E Grineski1, Ethan Siu Leung Cheung2, Austin S Clark3
1Ph.D. Department of Sociology, University of Utah, Salt Lake City, Utah, USA.
概括
较高暴露于细颗粒物 (PM2.5) 与加速的认知衰老有关,特别是执行功能. 心脏代谢性疾病部分调解了这种效应,突出显示了气候变化对健康的间接影响.
科学领域:
- 环境健康 环境健康
- 老年学是指老年学的学科.
- 流行病学 流行病学
背景情况:
- 预计气候变化将增加细颗粒物 (PM2.5) 污染.
- 暴露于PM2.5与加速衰老,认知衰退和心脏代谢疾病有关.
- 健康状况在PM2.5对老化影响中的中介作用尚不清楚.
研究的目的:
- 调查PM2.5暴露与与衰老相关的认知和功能限制之间的关联.
- 检查心脏代谢疾病和抑郁症状是否调解这些关联.
主要方法:
- 利用了美国中年期研究 (MIDUS) 的纵向数据 (N≈5000,年龄32-84岁).
- 根据住所地址,使用人口普查区级五年年均值评估PM2.5暴露.
- 分析了横截面和纵向关联,通过心脏代谢疾病和抑郁症状测试中介作用.
主要成果:
- 增加的PM2.5暴露与下级执行功能在横截面和纵横两方面有关.
- 在PM2.5暴露和功能限制之间没有发现显著的关联.
- 心脏代谢性疾病部分介导了PM2.5和执行功能之间的横截面联系 (影响的8.1%).
- 抑郁症状没有显著调解观察到的关联.
结论:
- 这些发现强调了气候变化通过PM2.5可能对中年和老年人的认知健康产生负面影响的间接途径.
- 强调需要考虑介导性健康状况,如心脏代谢疾病,以了解PM2.5与衰老相关的影响.
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