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患者特征,实践模式和生物假体和机械大动脉置换后的结果的性别相关差异

Milos Matkovic¹, Igor Zivkovic², Slobodan Micovic²

¹Department of Cardiac Surgery, University Clinical Centre of Serbia, Belgrade, Serbia.

Interdisciplinary cardiovascular and thoracic surgery

|May 9, 2025

概括

接受主动脉置换 (AVR) 的女性患者年龄较大,临床情况较差,但中期存活率与男性相似. 65岁以下的男性患有生物假体门的死亡率更高,突出了AVR结果的性别差异.

科学领域:

心脏病学心脏病学
心脏外科手术心脏外科手术
生物医学工程生物医学工程

背景情况:

大动脉置换 (AVR) 是治疗大动脉疾病的关键手术.
了解患者特征和结果的性别差异对于个性化治疗策略至关重要.
之前的研究表明,两性之间AVR结果可能存在差异,需要进一步调查.

研究的目的:

为了研究基线特征,外科实践模式和AVR后的中期存活率的基于性别的差异.
分析假肢类型和患者假肢不匹配 (PPM) 对按性别分层的结果的影响.
确定影响AVR后死亡率的潜在性别特异性因素.

主要方法:

来自AVR注册表的连续患者的回顾性分析,随访3年.
根据性别和假肢类型 (机械与生物假肢) 分类的患者.
主要终点:三年全因死亡率. 小组分析包括年龄值和PPM.

主要成果:

女性比AVR的男性更年长,BMI更高,射出率更低.
女性接受生物假肢AVR的频率更高;两性之间3年死亡率没有显著差异.
女性有机械门的PPM率更高;男性显示机械门与生物假体门的死亡率降低,特别是在65岁以下.

结论:

女性AVR患者的年龄较大,临床状况较差,但获得与男性相似的中期生存率.
在女性中使用生物假肢和PPM的更高率并没有转化为更差的生存率.
男性,特别是65岁以下的男性,经历了生物假肢AVR的较高死亡率,这表明假肢选择的性别特异性考虑.

关键词:

大动脉门更换术生物假肢是一种生物假肢.机械假肢是一种机械假肢.患者假体不匹配假体不匹配性别差异的性别差异.幸存率幸存率生存率

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