与系统性红斑狼风险相关的体力活动:一项前性研究,包括401,745名个人
Boya Xu1, Pinglang Ruan2, Haijing Wu2,3
1Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, No. 172 Tongzipo Road, Yuelu District, Changsha, Hunan, 410013, China.
Rheumatology (Oxford, England)
|May 9, 2025
概括
定期体力活动 (PA) 与患有全身性红斑狼 (SLE) 的风险降低有关. 中等或高的PA水平显著降低了SLE的发病率,提供了保护性的健康益处.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 身体活动 (PA) 是一个重要的健康行为,具有潜在的生物效益.
- 之前没有研究过PA与系统性红斑狼 (SLE) 发病率之间的关联.
研究的目的:
- 为了前性地评估身体活动水平与系统性红斑狼 (SLE) 发病率之间的关联.
主要方法:
- 一项前性研究利用了401,745名英国生物库参与者的数据,这些参与者有PA数据,没有基线SLE.
- 衡量的主要结果是发生SLE事件的发生,平均随访时间为12.46年.
主要成果:
- 在随访期间,共发现了222例SLE病例.
- 与PA水平较低的人相比,中度或高PA水平的个体显示SLE发病率明显较低.
- 适度的PA与40%更低的风险相关,高的PA与31%更低的SLE发病风险相关,独立于其他因素.
结论:
- 中等到高水平的体力活动与患SLE的风险降低有关.
- 氨酸具有保护性的健康益处,特别是在中年和老年人中预防SLE.
- 抗胰岛素的好处因年龄而异,高抗胰岛素对早期发病的SLE更有效,中度抗胰岛素对晚期发病的SLE更有效.
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