通过积极监测估计输血相关的循环过载的发生率:系统性审查和元分析
Sandra K White1, Brandon S Walker2, Scott Potter1
1Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
Transfusion
|May 9, 2025
概括
输血相关的循环过载 (TACO) 是输血死亡的主要原因之一. 这项研究使用积极监测估计了TACO发生率,发现每1000名患者中有22.2例,每1000名输血单位中有2.2例.
科学领域:
- 血液学 血液学 血液学
- 关键护理医学 关键护理医学
- 公共卫生 公共卫生
背景情况:
- 输血相关的循环过载 (TACO) 是与输血相关的死亡的主要原因.
- 由于TACO经常被诊断不足,因此需要准确的发病率估计.
- 积极监测研究为了解TACO流行率提供了关键数据.
研究的目的:
- 系统地审查和元分析主动监控研究,以估计TACO的发生率.
- 量化每位患者,每位血液成分单位和每次输血事件的TACO率.
- 确定可能导致TACO发病率异质性的因素.
主要方法:
- 从1991年1月到2024年6月的出版物的系统审查和元分析.
- 包括通过积极监测在所有患者环境中报告TACO发生率的研究.
- 随机效应建模以估计聚合发病率和元回归以探索异质性.
主要成果:
- 包括22项研究,每1000名患者中TACO发病率为22.2.
- 估计的TACO发生率为每1000个输血血液成分 (红血细胞,血,血小板) 的2.2.
- 每次输血事件的发病率为6.3/1000,明显高于每单位的发病率.
结论:
- 积极监测显示,TACO的发病率很高,这突出显示了它是一个关键的输血风险.
- 发病率各不相同,最近的研究报告发病率更高.
- 在决定输血时,临床医生必须权衡TACO的定量风险.
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