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17β-雌二醇 (E2) 通过与ESR1相互作用来调节子宫内膜癌 (EC) 中的恶性病和干细胞

Xiaochao Xu¹, Xinzhi Dai², Cheng Huang^3,4

¹College of Food and Biological Engineering, Chengdu University, Chengdu, 610000, Sichuan, China.

Reproductive sciences (Thousand Oaks, Calif.)

|May 9, 2025

概括

雌激素 (E2) 治疗通过调节雌激素受体-1 (ESR1) 来减少子宫内膜癌干细胞 (ECSC) 的干细胞和恶性病变. 对于雌激素来说,ESR1是至关重要的.

科学领域:

妇科瘤学妇科瘤学
癌症干细胞生物学
内分泌学在内分泌学.

背景情况:

子宫内膜癌 (EC) 是一种常见的妇科恶性瘤,与雌激素有关.
子宫内膜癌类干细胞 (ECSCs) 驱动了EC进展,但其由雌激素的调控尚不清楚.
雌激素受体-1 (ESR1) 是雌激素信号传递的关键媒介.

研究的目的:

调查ESR1在调节ECSCs干度和在雌激素 (E2) 影响下恶性潜力的作用.
确定E2是否通过ESR1介导的途径影响ECSC.
探索ESR1作为一个潜在的治疗目标在EC.

主要方法:

在EC组织中进行ESR1表达分析.
在EC细胞中操纵ESR1表达 (过度表达和淘汰).
评估E2对ECSC的影响:扩散,球体形成,入侵,殖民地形成和EMT标记表达.

主要成果:

ESR1对于E2对EC细胞的调节作用至关重要.
在ECSC中,E2治疗显著降低了干性标记物 (CD133,CD44,ALDH1) 和抑制恶性行为 (扩散,入侵,瘤形成).
E2显著抑制了表皮细胞-介质细胞过渡 (EMT) 标志物 (ZEB1,ZEB2,E-cadherin).

结论:

通过在雌激素的存在下调节ECSC的干度,ESR1在调节EC进展方面发挥着至关重要的作用.
ESR1调解了雌激素对EC干和恶性瘤的抑制作用.
ESR1代表了子宫内膜癌的潜在治疗标.

关键词:

17β-雌二醇 (E2) 是一种17β-雌二醇.子宫内膜癌类似干细胞 (ECSC)子宫内膜癌 (EC) 是一种内膜癌.皮质 - 介质细胞过渡 (EMT)雌激素受体-1 (ESR1) 是一种

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