检查持久有机污染物和代谢相关脂肪肝疾病之间的关系:使用NHANES数据进行横截面分析
Carlina Colussi1,2,3, Jean-Patrice Baillargeon4,5,6, Gérard Ngueta5,7
1Université de Sherbrooke, Faculté de Médecine Et Des Sciences de La Sante, Sherbrooke, Canada. carlina.colussi@usherbrooke.ca.
概括
持久性有机污染物 (POP) 可能会影响代谢相关脂肪肝疾病 (MAFLD) 的风险. 一些POP,如PCB,与MAFLD患病率呈反向关联,特别是在女性中,这表明性别特异性影响.
科学领域:
- 环境健康 环境健康
- 肝病学 肝病学是一种肝病学.
- 毒理学 毒理学 毒理学
背景情况:
- 代谢相关的脂肪肝疾病 (MAFLD) 越来越被认可,与饮食和活动以外的环境因素的潜在联系.
- 持久性有机污染物 (POP) 被怀疑是MAFLD的贡献者,即使在低暴露水平,需要进一步调查.
研究的目的:
- 调查暴露于持久性有机污染物 (POP) 和代谢相关脂肪肝疾病 (MAFLD) 的患病率之间的关联.
- 探索在POP暴露和MAFLD患病率之间的关系中的潜在的性别特异性.
主要方法:
- 采用4224名参与者的国家健康和营养检查调查 (NHANES) 数据进行的横截面研究.
- 考克斯回归分析以估计MAFLD的调整流行率 (aPR).
- 使用危险指数 (HI),最大缩放比例 (POMS) 和毒性负担指数 (TBI) 评估POP混合物.
主要成果:
- 总体而言,对于个别的POPs和MAFLD患病率,没有发现显著的性别差异.
- 敏感性分析表明,某些POPs和MAFLD流行率之间存在反向关系,特别是在女性中.
- 特定多双 (PCB) 的较高水平与女性的MAFLD患病率较低有关.
结论:
- 生物性别和代谢性压力因素显著影响着POPs如何影响MAFLD.
- 综合暴露评估方法 (HI,POMS,TBI) 提供了详细的风险评估.
- 需要进行进一步的研究,以阐明不同POP暴露范围和性别的机制和健康结果.
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