探索原发性免疫缺陷疾病的成年患者的非传染性放射性肺部发现
Filiz Sadi Aykan1, Fatih Çölkesen2, Recep Evcen3
1Division of Clinical Immunology and Allergy, Department of Internal Medicine, Ankara Health Sciences University Gülhane Training and Research Hospital, Ankara, Türkiye; drfilizsadi@gmail.com.
Allergologia et immunopathologia
|May 9, 2025
概括
放射性肺部发现,如支气管切除,在原发性免疫缺陷疾病 (PID) 中很常见. 异常发现与晚期诊断,较低的免疫细胞水平和较高的死亡率相关,突显了PID患者早期检测的必要性.
科学领域:
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
- 肺部病理学 肺部病理学
背景情况:
- 初级免疫缺陷疾病 (PID) 经常涉及呼吸道,支气管切除是常见的表现.
- 在PID患者中进行的比较放射学研究是有限的,需要进一步调查肺部参与模式.
研究的目的:
- 用高分辨率计算机断层扫描 (HRCT) 来调查成人PID患者的放射性肺部发现.
- 评估临床,免疫学特征和呼吸功能与PID的放射学发现之间的关系.
主要方法:
- 在116名成人PID患者中评估了人口统计学,临床,血清免疫球蛋白 (Ig),淋巴细胞亚组,HRCT和肺功能测试 (PFT).
- 在有和没有异常肺成像的患者之间比较HRCT发现.
主要成果:
- 在55.2%的患者中存在异常的HRCT发现,其中支气管切除症 (30.2%),双边参与 (73.5%) 和下叶占主导地位是最常见的.
- 患有异常HRCT的患者在诊断时年龄较大,IgG,IgA,IgM,CD4+T细胞,CD4+/CD8+比率和类切换记忆B细胞水平较低.
- 阻塞模式在PFT中最常见,HRCT异常患者的死亡率更高.
结论:
- 非传染性肺部并发症对PID的发病率和死亡率有显著的贡献,可能导致慢性肺病.
- 临床,免疫学和PFT参数,以及HRCT发现,可以帮助预测PID诊断,指导治疗和降低死亡率.
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