CHA2DS2-VASc评分作为心房的复发和肺静脉隔离后临床结果的预测指标
Mustafa Gabarin1, Mahmoud Suleiman2,3, Adi Elias2
1Cardiology Department, Meir Medical Center, Kfar-Saba and Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
概括
CHA2DS2-VASc评分预测心房 (AF) 复发和肺静脉隔离 (PVI) 后的不良结果. 这一分数可以帮助在经过切除术的AF患者中分层风险.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 医疗信息学 医疗信息学
背景情况:
- 心房动 (AF) 是一种常见的心律失常,与中风和心力衰竭等严重的心血管问题有关.
- 肺静脉隔离 (PVI) 是AF的标准治疗方法.
- 通常用于中风风险的CHA2DS2-VASc得分尚未完全评估,用于预测现实世界的PVI结果.
研究的目的:
- 评估CHA2DS2-VASc得分和PVI后AF复发之间的关系.
- 确定CHA2DS2-VASc评分是否预测PVI后的不良临床结果.
主要方法:
- 一项对860名患者进行的回顾性队列研究,这些患者首次接受了针对AF的PVI,该研究使用以色列导管切除注册表 (ICAR) 进行.
- 患者被分为两层,分为CHA2DS2-VASc得分组:0-1,2-4和>5.5.
- 主要终点是12个月内AF复发;次要终点包括再住院,主要不良心血管事件 (MACE) 和全因死亡率.
主要成果:
- 在32%的患者中观察到AF复发,在低,中等和高CHA2DS2-VASc分数组中分别为25.7%,31.4%和51%的发病率.
- 较高的CHA2DS2-VASc得分独立预测了AF复发风险的增加 (HR=2.88).
- 较高的分数与较高的MACE和再住院率相关,但并非全因死亡率.
结论:
- CHA2DS2-VASc评分是PVI后AF复发和不良结果的独立预测指标.
- 它的易用性和可用性使得它在接受切除的AF患者的手术前风险分层中非常有价值.
相关概念视频
Chi-square Analysis
35.6K
The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an observed value. In the context of genetics, it enables us to either accept or reject a hypothesis, based on how much the observed values deviate from the expected values.
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
35.6K
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
5.6K
All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the...
5.6K
Chi-square Distribution
3.4K
How does one determine if bingo numbers are evenly distributed or if some numbers occurred with a greater frequency? Or if the types of movies people preferred were different across different age groups or if a coffee machine dispensed approximately the same amount of coffee each time. These questions can be addressed by conducting a hypothesis test. One distribution that can be used to find answers to such questions is known as the chi-square distribution. The chi-square distribution has...
3.4K
Finding Critical Values for Chi-Square
2.9K
Consider a curve representing sample data drawn randomly from a normally distributed population. One must construct confidence intervals to estimate or to test a claim regarding the population standard deviation. For example, a 95% confidence interval covers 95% of the area under the curve, and the remaining 5% is equally distributed on either side of the curve. To achieve such confidence intervals, one must determine the critical values. The critical values are simply the values separating the...
2.9K
Chair Conformation of Cyclohexane
14.1K
The chair conformation is the most stable form of cyclohexane due to the absence of angle and torsional strain. The absence of angle strain is a result of cyclohexane’s bond angle being very close to the ideal tetrahedral bond angle of 109.5° in its chair conformer. Similarly, the torsional strain is also absent owing to the perfectly staggered arrangement of bonds.
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this...
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this...
14.1K
Chirality
22.4K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
22.4K


