一个纵向研究的双向时间动态之间的身体质量指数和生物衰老之间的纵向研究
Peggy Ler1, Jonathan K L Mak1,2, Chandra A Reynolds3
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.
Journal of cachexia, sarcopenia and muscle
|May 9, 2025
概括
较高的体重指数 (BMI) 加快了生物衰老,以脆弱指数 (FI) 衡量. 加速衰老反过来又导致晚年体重减轻,这表明需要对老年人进行综合肥胖和体重管理.
科学领域:
- 老年学是一门学科.
- 肥胖研究的研究.
- 生物医学科学 生物医学科学
背景情况:
- 肥胖和衰老共享生物通路,但它们在生命晚期的相互作用尚未完全理解.
- 研究身体质量指数 (BMI) 和生物衰老之间的关系对于管理与年龄和肥胖有关的健康风险至关重要.
- 本研究研究了老年人BMI变化与生物衰老标志物 (脆弱指数 (FI) 和功能衰老指数 (FAI)) 之间的双向,纵向关联.
研究的目的:
- 确定身体质量指数 (BMI) 与生命晚期的生物衰老 (脆弱指数[FI],功能衰老指数[FAI]) 之间的双向关系.
- 了解BMI的变化如何影响随着时间的推移生物衰老.
- 评估生物衰老如何影响老年人BMI轨迹.
主要方法:
- 从1986年到2014年使用瑞典双胞胎注册表替代研究 (GENDER,OCTO-Twin,SATSA) 的数据进行了纵向队列研究.
- 分析了来自瑞典60岁至91岁的双胞胎的6216-6512次评估.
- 应用双变化得分模型来评估BMI与FI或FAI之间的双向关联.
主要成果:
- 更高的BMI预测FI的增加更大 (合效应γ=0.86),更高的FI预测BMI下降更快 (γ=-0.04).
- 体重指数显示出非线性轨迹,75岁后下降更快,FI增加,特别是在60-75岁之间.
- 更高的FAI预测了更的BMI下降 (γ=-0.02),BMI在75岁后迅速下降,FAI指数呈指数增长.
结论:
- 肥胖 (更高的BMI) 似乎加快了生物衰老 (增加FI).
- 加快的生物衰老 (FI和FAI) 会导致生命晚期的BMI下降,这表明体重减轻可能源于衰老.
- 需要一个综合的方法来管理肥胖和老年人的无意减肥,因为它们的复杂相互作用.
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