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Updated: Jul 1, 2026

Identification of Functional Protein Regions Through Chimeric Protein Construction
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蛋白质溶解向金马 (PROTAC):化学生物学研究的一个革命性的工具

Meichen Pan1,2, Zhongliang Fu1,2, Hongwei Hou1

  • 1Beijing Life Science Academy, Beijing, 102209, China.

Small methods
|May 9, 2025
PubMed
概括

化向化体 (PROTAC) 技术通过降解蛋白来彻底改变药物发现. 本综述记录了PROTAC开发的里程碑和治疗应用的未来方向.

关键词:
这就是PROTAC.生物化学方法 生物化学方法发现药物的发现.有针对性的蛋白质降解降解.

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...