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益生菌作为精神疾病的技术创新:专利和研究评论

Alyne Almeida de Lima¹, Sthefane Silva Santos², Mykaella Andrade de Araújo³

¹Gonçalo Moniz Institute, Oswaldo Cruz Foundation-FIOCRUZ, Salvador, Brazil.

Frontiers in nutrition

|May 9, 2025

概括

益生菌通过影响肠-大脑轴,显示出对焦虑和抑郁症治疗的潜力. 创新重点是制药产品和功能性食品,主要使用乳酸菌和双菌菌株.

科学领域:

微生物学微生物学
神经科学是一个神经科学.
精神病学是一个精神病学.

背景情况:

益生菌调节肠-大脑-微生物群轴,显示出对焦虑和抑郁的希望.
对益生菌创新和市场的商业和学术兴趣越来越大.

研究的目的:

探索益生菌用于管理焦虑和抑郁症的创新趋势.
审查新型益生菌技术在精神疾病中的治疗应用.

主要方法:

在 Espacenet 数据库中进行专利搜索.
在ClinicalTrials.gov和ScienceDirect上进行额外的搜索.
对益生菌产品类型,作用机制和细菌种类的分析.

主要成果:

益生菌创新被开发为制药产品 (24.1%),功能性食品 (20.4%),或两者 (51.8%).
益生菌菌株通过神经递质调节 (61.1%),神经内分泌介质 (35.2%) 和神经炎症/氧化应激降低 (20.3%),表现出抗焦虑/抗抑郁作用.
乳杆菌 (48.1%) 和Bifidobacterium (38.9%) 属最常与这些影响有关. 确定了1945篇出版物和11项临床试验.

结论:

新型益生菌技术为精神疾病提供治疗潜力.
将学术发现转化为专利创新具有挑战.
需要进一步的研究和对益生菌创新的投资,以促进心理健康.

关键词:

抗抑郁药是一种抗抑郁药.焦虑缓解剂是一种焦虑缓解剂.创新创新创新创新创新创新 patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent 益生菌是一种益生菌.审查审查审查审查审查审查

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