臭氧化血液在重症COVID-19患者的治疗疗效:一个随机对照试验
Shokrollah Salmanzadeh1, Behnam Sheibani2, Saeid Bitaraf3
1Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Frontiers in medicine
|May 9, 2025
概括
这项试点研究调查了重症COVID-19的臭氧治疗 (OT),发现住院时间没有显著差异,但ICU转移和死亡风险更高. 需要进一步的研究来评估OT.
科学领域:
- 医学研究 医学研究
- 临床试验中的临床试验.
- 传染病管理 传染病管理
背景情况:
- 臭氧治疗 (OT) 已证明具有抗炎,抗微生物和免疫调节性质.
- 疫情前的研究表明,臭氧气对各种疾病有潜在的益处.
- 随着COVID-19的流行,人们开始研究新的治疗方法,如OT.
研究的目的:
- 评估血液臭氧治疗 (OT) 作为严重COVID-19的研究药物的结果.
- 为了比较OT与标准护理相结合和单独标准护理.
- 在试点随机对照试验中评估OT的安全性和有效性.
主要方法:
- 一项试点随机对照试验在60名患有严重COVID-19的患者中进行.
- 两组人都按照伊朗卫生部的指导方针接受了标准的护理.
- 干预组除了接受标准护理外,还接受了静脉内臭氧化血液治疗.
主要成果:
- 臭氧治疗 (OT) 显示,长时间住院的风险比率高出33%,但不具有统计学意义.
- 接受OT治疗的患者在ICU转移时的几率比率 (4.3) 显著更高.
- 单变量分析表明,与OT相关的死亡概率增加了3.5倍,但不显著.
结论:
- 在这项试点研究中,臭氧治疗 (OT) 对严重的COVID-19没有明显的好处.
- 潜在的不利结果,包括增加ICU转移和死亡风险,需要谨慎.
- 需要对更多人群进行进一步的强大试验,以确定OT在严重COVID-19治疗中的作用.
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