全球抗生素耐药性的模式在B组菌:一个系统的审查和元分析
Chou-Yi Hsu1, Safoura Moradkasani2, Muath Suliman3
1Thunderbird School of Global Management, Arizona State University Tempe Campus, Phoenix, AZ, United States.
Frontiers in microbiology
|May 9, 2025
概括
在全球范围内,B组链球菌 (GBS) 的抗生素耐药性正在上升,四环素的高率和许多抗生素的增加趋势. 这凸显了迫切需要更好的监督和管理.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 乙组链球菌 (GBS) 是新生儿严重感染的主要原因,如败血症和脑膜炎.
- 在GBS菌株中抗生素耐药性的增加构成了全球重大公共卫生威胁.
研究的目的:
- 进行全面的元分析,评估GBS菌株抗生素耐药性的全球流行情况.
- 识别不同地区和时间的GBS抗生素耐药性的趋势和差异.
主要方法:
- 在四个主要数据库 (Scopus,PubMed,Web of Science,EMBASE) 进行系统搜索,截至2023年12月.
- 使用随机效应模型进行元分析,结合子组分析和回归.
- 266项的质量评估包括来自57个国家的研究,使用乔安娜·布里格斯研究所的工具.
主要成果:
- 对四环素 (80.1%) 观察到高耐药率,对泰迪索利德 (0.1%) 观察到低耐药率.
- 抗阿齐思罗米和甘他的显著异质性 (I2=97.29%),但对于tigecycline和ceftaroline没有 (I2=0%).
- 对克林达米辛,红素,诺类药物和其他药物的抗药性趋势越来越强;对牛素的抗药性呈现下降趋势.
结论:
- 在GBS中抗生素耐药性是一个日益关注的问题,具有显著的区域和方法差异.
- 越来越多的抗生素耐药性趋势迫切需要全球监测和改善抗生素管理.
- 该研究强调需要更新治疗指南和策略,以对抗GBS感染.
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