产前期母亲吸烟与子女便秘的风险增加有关:来自孟德尔随机化研究的证据
Yong Shen1,2, Siqi Xie1, Yu Lin1
1Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Tobacco induced diseases
|May 9, 2025
概括
母亲在出生前期吸烟与后代便秘的风险更高有关. 这项遗传研究使用了门德尔的随机化来探索母亲吸烟与儿童便秘之间的关联.
科学领域:
- 生殖健康 生殖健康
- 儿科健康 儿科健康
- 遗传流行病学遗传流行病学
背景情况:
- 怀孕期间母亲吸烟是众所周知的各种不良后代健康结果的危险因素.
- 便秘是婴儿和儿童常见的胃肠道问题,影响受影响家庭的生活质量.
研究的目的:
- 调查母亲在出生前期吸烟与后代便秘发生率之间的潜在因果关系.
- 利用强大的遗传方法,门德尔的随机化,推断因果关系和减轻混因素.
主要方法:
- 采用两个样本的门德尔随机化 (MR) 设计,使用来自MR Base平台的全基因组关联研究 (GWAS) 数据.
- 利用单核酸多态 (SNPs) 强烈地与母亲在出生前后的吸烟有关,作为仪器变量.
- 应用了多种MR分析方法,包括反变量加权 (IVW),加权中位数估计器和MR-Egger回归,以评估相关性.
主要成果:
- 确定了20个与出生前期母亲吸烟相关的显著SNP.
- 跨方法一致的证据表明,母亲在分娩前吸烟与子女便秘风险增加之间存在积极联系 (例如,IVW OR=4.35,95% CI:1.81-10.45).
- 没有发现有意义的证据表明,对便的遗传责任对母亲吸烟的反向因果作用.
结论:
- 这项研究提供了遗传证据,表明母亲在出生前吸烟与后代便秘风险增加之间存在联系.
- 研究结果强调了在怀孕期间戒烟对于改善儿童健康状况的重要性.
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