观察间变异对肺结节的放射性特征的影响
Wenchao Zhu1,2, Fangyi Xu1,2, Kaihua Lou1,2
1Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Frontiers in oncology
|May 9, 2025
概括
肺结节的大部分放射性特征是稳定的,尽管有间观测细分的变化. 原始和LOG特征显示出高稳定性,而波形特征更容易受到影响,突出显示了在放射学研究中需要一致的细分.
科学领域:
- 放射学 放射学是一门学科.
- 医疗成像医学成像
- 计算病理学计算病理学
背景情况:
- 放射学从医学图像中提取定量特征.
- 兴趣区域 (ROI) 分段中的观测间变化 (IOV) 可以影响放射学结果.
- 标准化放射学分析对于可靠的肺结节性状表征至关重要.
研究的目的:
- 系统地分析肺结节的放射性特征.
- 评估IOV在ROI细分中的对放射性特征稳定的影响.
- 为肺结节放射学研究提供参考数据.
主要方法:
- 由六名临床医生和人工智能算法对232个肺结节进行手动细分.
- 由专家确立的细分作为参考标准.
- 使用直径测量,ROI一致性和放射性特征稳定性分析 (OCCC) 评估IOV.
主要成果:
- 85.96%的放射性特征表现出良好的稳定性 (OCCC ≥0.75),其中61.48%显示出非常好的稳定性 (OCCC ≥0.90).
- 原始,LOG和波形特征通常表现出高稳定率 (>80%).
- 原始和LOG特征显示出高稳定性 (OCCC中位数:0.92-0.95),LOG特征的性能略高于波形特征,波形特征更容易受到IOV的影响.
结论:
- 虽然IOV会影响肺结节的放射性特征,但大多数仍保持稳定.
- 一致的细分ROI定义是最小化IOV效应的关键.
- 原始和LOG特征是强大的,而波形特征需要仔细考虑,因为它们更容易受到细分变化的影响.
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