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Updated: May 5, 2026

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生物工程技术的现状 在贝塔细胞替代方法中的方法

Jake Miller1, Quentin Perrier1,2,3, Arunkumar Rengaraj1,2

  • 1Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC USA.

Current transplantation reports
|May 9, 2025
PubMed
概括

胰腺小岛生物工程的进步为1型糖尿病 (T1D) 治疗提供了新的希望. 研究人员正在探索脱细胞化矩阵,3D生物打印和干细胞衍生器官,用于β细胞替代疗法.

关键词:
生物工程是生物工程.生物打印是一种生物打印技术.细胞外矩阵是细胞外矩阵.在一个芯片上的小岛.小小的岛屿 小小的岛屿1 型糖尿病 1 型糖尿病

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The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
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